High yield [18F]FET production on AllinOne (Trasis) at commercial scale
O-(2-[18F] fluoroethyl)-L-tyrosine ([18F]FET), a 18F-labeled amino acid for imaging amino acid metabolism in tumors, shows high uptake in the primary brain tumors (PBT). [18F]FET overcomes disadvantages of [18F]FDG and [11C] methionine tracers: [18F]FET is more specific than FDG and benefit from the longer half-life versus [11C] tracers. Accordingly, [18F]FET PET is a highly relevant tool for patient management [1-3]. Therefore, a robust synthesis combined with a high yield is requested and has been achieved by Trasis on the AllinOne synthesizer (Figure 1). This process requires no preparation prior to production, operates on ready-to-use consumables and facilitates implementation of GMP.
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