Clinical validation of the novel HDAC6 radiotracer [¹⁸F]EKZ-001 in the human brain

Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that modulates intracellular transport and protein quality control. Inhibition of HDAC6 deacetylase activity has shown beneficial effects in disease models, including Alzheimer’s disease and amyotrophic lateral sclerosis. This first-in-human positron emission tomography (PET) study evaluated the brain binding of [¹⁸F]EKZ-001 ([¹⁸F]Bavarostat), a radiotracer selective for HDAC6, in healthy adult subjects.

[18F]EKZ-001 on AllinOne

[¹⁸F]EKZ-001 on AllinOne