Production of [¹⁸F]F-Py-TFP as a secondary labelling precursor on a cassette based synthesis unit towards a GMP-compliant and convenient fluoroarylation of [¹⁸F]-peptides and [¹⁸F]-peptidomimetics

The synthesis and purification of prosthetic groups for the radiofluorination of peptides are sophisticated and therefore difficult to translate into routine production. The aim is to transfer the synthesis of [¹⁸F]F-Py-TFP (6-[¹⁸F]fluoronicotinic acid 2,3,5,6-tetrafluorophenyl ester) as reported by Olberg et al. onto a cassette-based radiosynthesizer for large-scale GMP-compliant automated production ready for subsequent labelling of peptides. Materials and Methods: An aqueous solution containing [¹⁸F]fluoride was obtained by nuclear reaction (18O(p,n)18F) from a Scanditronix MC32NI cyclotron, transferred to a Trasis AllinOne synthesis module, trapped on and eluted from a QMA cartridge using TBA-HCO3 in water and acetonitrile as the eluent …

[18F]F-Py-TFP on AllinOne

[¹⁸F]F-Py-TFP on AllinOne